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14 09, 2023
Study Provides New Insight for Prevention and Treatment of Colon Cancer by Probiotics Intervention
In a recent study published in Microbiology Spectrum, the researchers at the Institute of Modern Physics (IMP) of the Chinese Academy of Sciences (CAS) suggested that the intervention of probiotics is a potentially feasible strategy for preventing colon cancer.
As the second leading cause of cancer-related deaths, colorectal cancer has become the third most common cancer followed by breast cancer and lung cancer. Most patients are diagnosed at the middle and advanced stages owing to the longer development of malignancies in the colon and rectum, as well as higher concealment compared to other cancers, which results in a narrow treatment window and higher mortality rate. Thus, efficient and safe prevention strategies for colon cancer in early stages are essential for its management.
Gut microbiota and their secreted metabolites have a significant influence on the initiation and progression of colon cancer. Therefore, the prevention and treatment of colon cancer based on the regulation of intestinal microflora by probiotics has become a frontier research topic in tumor biology.
The researchers at IMP have irradiated probiotic JY strain by heavy-ion beams, and obtained an excellent mutant strain JY300-8 through selections of transit tolerance in the upper human gastrointestinal tract. In addition, from the intestine of mice with complete tumor remission, researchers isolated a strain of L. reuteri with a strong anti-proliferation ability on tumor cell.
Having investigated the preventive and therapeutic efficacy of Lactobacillus for colon cancer, researchers found that the inhibition rates of these probiotics against mice colon cancer cells and human colon cancer cells were more than 50% and 70% respectively, which reached a higher level in similar research. They also found that dual probiotics could reduce the tumor formation rate and tumor volume, and could significantly inhibit the progression of tumors in colon cancer susceptible models in mice.
The researchers also revealed the underlying antitumor mechanism through the alteration of gut microbiota and their metabolites.
Additionally, the researchers have combined the carbon ion radiation therapy with the opsonization of gut microbial therapy for the first time, which increases the survival rate of colon cancer model in mice by 50% compared with the control group.
This research has enriched the resource of probiotics, and provided a tumor treatment strategy by combining the carbon ion radiotherapy with the gut microbial therapy, laying a theoretical foundation for the precise prevention and management of colon cancer.
This work was supported by the “HONGGUANG” Special Project of CAS, National Natural Science Foundation of China and Key Research and Development Programs of Gansu Province.
DOI:
Figure 1. Graphical representation of major microbial and metabolomic alterations correlated with the tumorigenesis and the progression of colon cancer. (Image by XU Fuqiang, WANG Shuyang)
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Institute of Modern Physics
Email: fangliu@impcas.ac.cn
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