First applied proteomic approach to profile sperm motility markers in mice after carbon ion radiation

Ion radiation or radiotherapy may cause male with oligozoospermia, azoospermia, temporarily infertility, or even permanent infertility. The decline of sperm motility is the most important factor leading to infertility. However, the mechanisms underlying motility abnormalities remain poorly understood after ionizing radiation.

The relationship between low sperm motility and proteins has been investigated by the researchers in the department of Heavy Ion Radiation Medicine, Institute ...


Compared with conventional radiation, the heavy ion beam represents a more favorable and ideal modality for the deep-seated tumors due to its better depth dose distribution which the dose increases with penetration depth up to a sharp maximum at the end of the particle ranges and smaller scattering which allows irradiation of deep-seated target volumes with optimum precision and enhanced relative biological effectiveness resulting in reduced cellular repair while providing an optimal sparing of the neighboring normal tissues. While the pioneering research work and practice of heavy ion therapy for cancer treatment were conducted decades ago in the United States, Germany and Japan, our major tasks at IMP are to investigate the mechanisms underlying heavy ion irradiation induced biological effects and conduct clinical trials of heavy ion therapy on various cancer types to provide technical and basic research support for its future development and boost its actual use in China.

 

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Achievement

Over the past decade, we had conducted pilot clinical trial in cooperation with local hospitals and medical institutions from November, 2006. Up to date, 103 clinical trials for superficially-placed tumor and related 4-year follow-up surveillance have been completed successfully. The statistics show the total 4-year survival rate of all patients exceeded 60% without significant radio-related side effects observed. From March, 2009 to present, 73 clinical trials for deep-seated visceral tumor were carried out totally. Primary results show an improved long term survival rate and better post operational life quality compared with conventional treatment which indicates heavy ion therapy is effective and advantageous for inoperable and recurrent visceral tumors.

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